Acrylic Chip
Acrylic Chip - Related Videos
09:58
Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays
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Cited by 1 •
2022
Microfluidics is a powerful tool for the development of diagnostic tests. However, expensive equipment and materials, as well as laborious fabrication and handling techniques, are often required. Here, we detail the fabrication protocol of an acrylic microfluidic device for magnetic micro- and nanoparticle-based immunoassays in a low-cost and simple-to-use setting.
06:12
Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System
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2025
Here we present a protocol for constructing an organ-on-chip (OOC) system designed to mimic pneumonectomy. This system investigates the potential correlation between glycocalyx impairment and complications following pneumonectomy.
07:51
Acrylic Resin Molding Based Head Fixation Technique in Rodents
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Cited by 4 •
2016
Traditional head fixation techniques have used metallic frames attached on the skull as an interface for head fixation apparatus. This protocol demonstrates a frameless, acrylic resin molding based head fixation technique for behavioral tasks in rodents.
11:17
Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction
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Cited by 115 •
2016
A novel methodology is presented to synthesize and program main-chain liquid-crystalline elastomers using commercially available starting monomers. A wide range of thermomechanical properties was tailored by adjusting the amount of crosslinker, while the actuation performance was dependent on the amount of applied strain during programming.
07:50
Chip-Based Digital PCR to Detect Rare Transcript Variants Using a Nanofluidic Chip
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2025
This video demonstrates chip-based digital PCR — a variation of the digital PCR technique that is useful in detecting rare transcript variants. The PCR reaction is partitioned into the chambers of a nanofluidic chip, each of which acts as an independent reaction. The detection of fluorescence signals from the chambers with amplified targets confirms the presence of rare transcript variants in the sample.
FAQs
Fluid movement is controlled through the chip’s microscale channels and chambers using either pressure-driven flow or capillary flow. Pressure supplies an external force to move liquid, whereas capillary flow guides liquid through the device without the same type of applied pressure. Selecting between these modes helps researchers organize sample transport for assays, preparation steps, and biochemical reactions.
The arrangement of microscale channels and chambers determines where fluids, cells, or reactions are positioned within the device. These features create separate regions for guiding liquids and organizing experimental steps in a compact format. Their layout therefore influences how the chip supports sample preparation, cell culture, biochemical assays, or biosensing workflows.
Transparent acrylic layers allow researchers to observe activity inside the device while an experiment is underway. This supports real-time observation and imaging of fluids, cells, or assay-related changes without relying only on measurements made after the experiment. In bioengineering studies, that visibility helps connect the chip’s internal organization with the observed experimental outcome.
Fabrication begins by forming acrylic layers and creating microscale channels or chambers through machining, laser cutting, or related methods. The patterned layers are then sealed so liquids can travel through the intended pathways. This sequence produces a contained device in which fluid routing, sample handling, and reaction organization can be controlled within the assembled chip.
Researchers may choose this platform when they need a compact format for microfluidic assays, cell culture, sample preparation, or biosensing. Its transparent construction is useful when the experiment requires direct observation or imaging. The same platform also supports development of portable diagnostic systems and other lab-on-a-chip technologies.
Acrylic chips can reduce the volume of reagents required and shorten analysis times by organizing experimental operations within microscale channels and chambers. These features make the platform useful for efficient assays and sample processing. The resulting format can also support portable diagnostic development, where compact device designs are important for lab-on-a-chip applications.
Within bioengineering, acrylic chips provide a structured setting for cell culture, biochemical reactions, sample preparation, and biosensing. Researchers can guide liquids through sealed pathways while observing the device through its transparent layers. This combination of controlled fluid handling and visual access supports the study and development of microscale experimental systems.