Polymer Shell Encapsulation

Polymer shell encapsulation is a chemical strategy that surrounds a liquid, solid, or biological core with a protective polymer layer, creating core-shell particles with controlled properties. The shell forms when polymer chains assemble, precipitate, cross-link, or polymerize at the core interface, regulating transport through factors such as thickness, porosity, composition, and degradation rate. In chemistry, this approach helps stabilize reactive or sensitive compounds, control the release of catalysts, drugs, fragrances, and agricultural agents, and separate materials from their surroundings. By tuning shell chemistry and processing conditions, researchers can improve storage stability, targeted delivery, and performance in coatings, sensors, catalysis, and advanced materials.

Polymer Shell Encapsulation - Related Videos

Research

JoVE EoE - Large Animal Models

3D Culture of Porcine COCs: A Procedure to Encapsulate Cumulus Oocyte Complexes in Fibrin-alginate Polymer Hydrogel Beads

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2025

This video describes the protocols for encapsulating porcine cumulus-oocyte complexes (COCs) in fibrin-alginate beads to establish a 3D culture. This in-vitro maturation system maintains normal cell-to-cell communication, ensuring oocyte maturation and retaining viability.

Research

JoVE Journal - Biology
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Cellular Encapsulation in 3D Hydrogels for Tissue Engineering

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Cited by 54 •

2009

We present protocols for the 3-dimensional (3D) encapsulation of cells within synthetic hydrogels. The encapsulation procedure is outlined for two commonly used methods of crosslinking (michael-type addition and light-initiated free radical mechanisms), as well as a number of techniques for assessing encapsulated cell behavior.

Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers

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2022

Here, we describe protocols for the preparation of trans-cyclobutane fused cyclooctenes (tCBCO), their polymerization to prepare depolymerizable olefinic polymers, and the depolymerization of these polymers under mild conditions. Additionally, protocols for the preparation of depolymerizable networks and compression molding of rigid linear plastics based on this system are described.

Research

JoVE Journal - Bioengineering
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Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

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Cited by 2 •

2023

This method describes the encapsulation of the rabies antigen into biodegradable polymeric microparticles with structural and material properties that enable pulsatile release after a predetermined delay. Enzyme-linked immunosorbent assay (ELISA) assessment of the antigen retrieved from the particle core confirms the presence of intact trimeric rabies virus glycoprotein through particle fabrication.

Research

JoVE Journal - Biology
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PuraMatrix Encapsulation of Cancer Cells

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Cited by 31 •

2009

This video demonstrates how to encapsulate and culture cancer cells in PuraMatrix, a commercially available self assembling peptide gel.

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