Explainable Machine Learning

Explainable machine learning (XAI) is a set of methods that makes a model’s predictions understandable to people, helping users assess reliability, detect errors, and make informed decisions. It works by relating inputs to outputs through techniques such as feature attribution, which estimates each variable’s contribution, surrogate models that approximate complex predictors, and counterfactual explanations that show how changing an input could alter a result. In engineering, XAI supports trustworthy monitoring, fault diagnosis, predictive maintenance, and safety-critical control by revealing influential conditions and potential model bias. These insights improve validation, accountability, and collaboration between domain experts and data-driven systems.

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Research

JoVE Journal - Engineering

Constructing and Visualizing Models using Mime-based Machine-learning Framework

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Cited by 4 •

2025

Mime is a flexible computational framework to construct a machine learning-based integration model with elegant performance. Here, we provide a detailed step-by-step procedure for developing predictive models with high accuracy, leveraging complex datasets to identify critical genes associated with disease progression, patient outcomes, and therapeutic response.

Asthma Detection Research Based on Voice Signal Processing and Machine Learning

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2025

This study employed voice signal analysis and machine learning methods, utilizing MATLAB to extract distinctive voice features for non-invasive early detection of asthma. The Support Vector Machine (SVM) and Random Forest (RF) algorithms demonstrated comparable performance in terms of overall classification accuracy, although SVM may achieve a better balance between sensitivity and specificity.

A Live-cell Image-Based Machine Learning Strategy to Monitor Pluripotent Stem Cell Differentiation

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2024

Available pluripotent stem cell (PSC)-to-functional cell differentiation systems are currently impeded by problems of severe line-to-line and batch-to-batch variability. Here, using cardiac differentiation as the main example, we present a protocol to intelligently monitor and modulate the process of PSC differentiation based on image-based machine learning.

Machine Learning-Based Cough Tone Classification: Diagnostic Exploration of Chronic Obstructive Pulmonary Disease and Respiratory Tract Infections

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2025

This study effectively accomplished the automated classification of two distinct categories by acquiring cough sound data from patients diagnosed with chronic obstructive pulmonary disease (COPD) and respiratory tract infections (RTI), utilizing an integration of speech signal processing techniques and machine learning algorithms.

Label-free, High-Resolution 3D Imaging and Machine Learning Analysis of Intestinal Organoids via Low-Coherence Holotomography

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Cited by 5 •

2025

We present a step-by-step protocol for high-resolution, label-free, and three-dimensional imaging of organoids using low-coherence holotomography. This protocol details organoid culture preparation, imaging acquisition, and computational image analysis, enabling real-time visualization of structural dynamics and drug responses in living organoids.

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