Macaulay Brackets

Macaulay brackets are a notation and calculation method in structural engineering for representing discontinuous or concentrated loads along beams within a single mathematical expression. Defined so that ⟨x−a⟩ⁿ equals zero before position a and (x−a)ⁿ after it, they activate each load term only when the beam coordinate reaches its point of application; repeated integration then yields shear force, bending moment, slope, and deflection equations. This singularity-function approach simplifies analysis of beams with multiple point loads, applied moments, or changes in distributed loading, reducing the need to write separate equations for each span and supporting efficient structural design checks.

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Research

JoVE Journal - Neuroscience

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

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Cited by 10 •

2023

Laboratory assays can leverage prognostic value from the longitudinal optical coherence tomography (OCT)-based multimodal imaging of age-related macular degeneration (AMD). Human donor eyes with and without AMD are imaged using OCT, color, near-infrared reflectance scanning laser ophthalmoscopy, and autofluorescence at two excitation wavelengths prior to tissue sectioning.

Research

JoVE Journal - Medicine
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A Workflow to Quantitatively Determine Age-Related Macular Degeneration Lesion-Specific Variations in Fundus Autofluorescence

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Cited by 2 •

2023

This research describes a workflow to determine and compare autofluorescence levels from individual regions of interest (e.g., drusen and subretinal drusenoid deposits in age-related macular degeneration [AMD]) while accounting for varying autofluorescence levels throughout the fundus.

Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography

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Cited by 4 •

2023

Currently, fluorescein angiography (FA) is the preferred method for identifying leakage patterns in animal models of choroidal neovascularization (CNV). However, FA does not provide information about vascular morphology. This protocol outlines the use of indocyanine green angiography (ICGA) to characterize different lesion types of laser-induced CNV in mouse models.

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

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Cited by 13 •

2014

Indocyanine Green Angiography (or ICGA) performed by tail vein injection provides high quality ICGA time course images to characterize abnormalities in mouse choroid.

Research

JoVE Journal - Medicine
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Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer

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Cited by 15 •

2020

We present a protocol to determine the levels of overall macular pigment, lutein, and zeaxanthin optical density in the central and parafoveal regions of the retina. The protocol includes a novel adjustable track system used to measure macular pigment optical density in the foveal eccentricity.

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