Thread Bolt Insertion

Thread bolt insertion is a neurosurgical technique that secures a monitoring device through the skull, providing controlled access to intracranial tissues and compartments. The procedure typically involves creating a small burr hole, positioning a threaded bolt in the cranial opening, and advancing a probe or catheter through the bolt while maintaining a stable seal. In neuroscience and neurocritical care, this approach supports continuous measurement of intracranial pressure and, depending on the device, collection of electrophysiological or biochemical data. Accurate placement and fixation are essential for reliable recordings, minimizing motion-related artifacts, and monitoring changes that can guide assessment of brain injury and neurological disease.

Thread Bolt Insertion - Related Videos

Research

JoVE EoE - Neuropathology

Inducing Ischemic Stroke via Middle Cerebral Artery Occlusion Using a Thread Bolt

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2025

This video demonstrates the process of inducing ischemic stroke in a rat model by occluding the middle cerebral artery (MCA) using a thread bolt. The procedure involves ligating the carotid arteries, inserting a thread bolt into the external carotid artery, and blocking blood flow from the MCA to the brain, leading to neuronal death and mimicking an ischemic stroke.

Research

JoVE Journal - Neuroscience

Operation Procedure and Precautions of Thread-Embedding Acupuncture Therapy in Alzheimer

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Cited by 1 •

2024

This study presents a protocol for thread-embedding acupuncture therapy in Alzheimer's disease-like rats.

Quantification of Tear Volume in an Autoimmune Dry Eye Rat Model using the Phenol Red Thread

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2025

This video demonstrates the phenol red thread test to determine tear volume in an autoimmune dry eye rat model. The pH-sensitive acidic phenol red thread changes color when it comes in contact with the alkaline tears. The shorter length of color change in the phenol red thread corresponds to reduced tear volume.

Phenol Red Thread-based Sampling Procedure for Untargeted Tear Fluid Lipidomics in Biomarker Discovery

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2025

This protocol describes a unique clinical protocol for collecting human tear fluid samples using phenol red threads and liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based workflow to discover the tear lipidomic profile. The simple methyl tert-butyl ether (MTBE)/methanol biphasic separation method enables rapid tear lipid extraction with high recovery for tear biomarker discovery.

Research

JoVE Journal - Behavior
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Medicated Thread Moxibustion Therapy of Zhuang Medicine and its Application in a Rat Model of Cold-Congealing Syndrome of Primary Dysmenorrhea

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Cited by 3 •

2024

This article demonstrates the standardized operation process of Zhuang medicine line moxibustion in experimental animals. To achieve repeatability and accuracy of Zhuang medicine line moxibustion, we developed a simulator to maintain strength, heat, and frequency. We constructed a dysmenorrhea model for experimental verification in rats with cold coagulation syndrome.

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