Kaplan-meier Method

The Kaplan-Meier method is a statistical approach for estimating the probability that individuals remain free of a defined event over time, making it valuable for analyzing time-to-event data. It constructs a stepwise survival curve by ordering observed event times, calculating survival probabilities at each event, and accounting for censored observations, in which follow-up ends before the event occurs. Researchers use Kaplan-Meier analysis to compare survival experiences between groups, assess treatment outcomes, and summarize the timing of events in clinical, epidemiological, and reliability studies. Its visual and quantitative representation supports interpretation of incomplete follow-up data and informs further statistical modeling.

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JoVE Core - Statistics

Kaplan-Meier Approach

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2025

The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...

Research

JoVE Journal - Medicine

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

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Cited by 1 •

2025

This study evaluates prognostic systems for colorectal signet-ring cell carcinoma patients using machine learning models and competing risk analyses. It identifies log odds of positive lymph nodes as a superior predictor compared to pN staging, demonstrating strong predictive performance and aiding clinical decision-making through robust survival prediction tools.

Research

JoVE Journal - Medicine
Free Sample

A Simple Guide Screw Method for Intracranial Xenograft Studies in Mice

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Cited by 14 •

2011

In order to evaluate novel therapeutic paradigms for the treatment of glioma, physiological relevant models are essential. We utilize an implantable guide screw procedure for establishment of intracranial xenograft models that is more rapid and safer than stereotactic approaches.

Research

JoVE Journal - Cancer Research

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

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2022

The present protocol describes the implantation and evaluation of melanoma in the murine choroid utilizing optical coherence tomography.

Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis

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Cited by 5 •

2023

The present protocol describes how to use a FeCl3-mediated injury to induce arterial thrombosis, and how to collect and prepare arterial injury samples at various stages of thrombosis for electron microscopy analysis.

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