Nir Qvit

Nir Qvit

https://orcid.org/0000-0002-2578-1048

Department of Chemical and Systems Biology, Stanford University School of Medicine

Affiliated withStanford University School of MedicineBar Ilan UniversityBar-Ilan University

Research Area

Biography

Nir Qvit is an Associate Professor in the Faculty of Medicine, Bar-Ilan University, Israel. He received his undergraduate and a Ph.D. in organic chemistry developing different strategies for the synthesis of small molecules and peptides, in solution and on a solid support, for various therapeutic applications from the Hebrew University of Jerusalem, Israel. Dr. Qvit overcame challenging synthesis and developed an innovative procedure for generating novel and highly bioactive protein-protein interaction inhibitors and was awarded the prestigious Kaye Innovation Award for demonstrating extraordinary creativity as a medicinal chemist.

During Dr. Qvit’s training, he developed a keen focus on research that encompasses the maintenance of mitochondrial homeostasis and cell fate. As a post-doctoral fellow (2008 to 2016) in Daria Mochly-Rosen’s lab at the Department of Chemical and System Biology in Stanford School of Medicine, Stanford, CA, USA, He developed and studied the roles of inhibitors that selectively regulates the protein-protein interactions between a kinase and its specific substrate among many, and he developed specific inhibitors of large GTPase to modulate excessive mitochondrial fission. These inhibitors are highly active in models of neurodegenerative disease and cardiovascular disease, and one molecule has been licensed to a biopharmaceutical company.

Dr. Qvit served as a chairman for multiple sessions of several conferences and was the Chair of the first: “Gordon Research Seminar: The Future of Peptides in Chemistry and Biology, 2012”. He received the prestigious Kaye Innovation Award for demonstrating extraordinary creativity as a medicinal chemist, the Burroughs Wellcome Fund Collaborative Research Grant, and the European Molecular Biology Organization (EMBO) Fellowship, and in 2017 he was recruited as faculty at Bar-Ilan University. His research focuses on the development of novel tools to regulate protein-protein interactions in a highly specific manner for basic research and for therapeutic applications.

JoVE Journal Publications

ArticleTotal : 2
Year
Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
Publication title

Cited by 10

2016
2022

Other Publications

Article
Year

Journal of combinatorial chemistry| PubMed ID: 18271560

2008

Biopolymers| PubMed ID: 18459171

2008

Biopolymers| PubMed ID: 19025995

2009

Trends in endocrinology and metabolism: TEM| PubMed ID: 19056296

2009

Advances in experimental medicine and biology| PubMed ID: 19400129

2009

Drug discovery today. Disease mechanisms| PubMed ID: 21151743

2010

Journal of cell science| PubMed ID: 23239023

2013

Chemical biology & drug design| PubMed ID: 25042903

2015

Biochemical Society transactions| PubMed ID: 25399565

2014

Circulation research| PubMed ID: 25999419

2015

Current topics in medicinal chemistry| PubMed ID: 29773062

2018

Current topics in medicinal chemistry| PubMed ID: 29773063

2018

Current topics in medicinal chemistry| PubMed ID: 30014801

2018

Scientific reports| PubMed ID: 30232469

2018

Biochimica et biophysica acta. Biomembranes| PubMed ID: 31738904

2020

Biochimica et biophysica acta. Biomembranes| PubMed ID: 32710853

2020

Current topics in medicinal chemistry| PubMed ID: 33050863

2020

Current topics in medicinal chemistry| PubMed ID: 33087030

2020

Current topics in medicinal chemistry| PubMed ID: 33297905

2020

Pharmaceuticals (Basel, Switzerland)| PubMed ID: 35337069

2022