Pdms Microfluidics
Pdms Microfluidics - Related Videos
04:45
Non-plasma Bonding of PDMS for Inexpensive Fabrication of Microfluidic Devices
0 Views •
Cited by 19 •
2007
In this video we demonstrate how to use the neuron microfluidic device without plasma bonding.
11:13
Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles
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Cited by 2 •
2016
We propose a simple self-assembly technique of silica colloidal nanoparticles to create a nanofluidic junction between two microchannels in polydimethylsiloxane (PDMS). Using this technique, a nanoporous bead membrane with a pore size down to ~45 nm was built inside a microchannel and applied to electrokinetic preconcentration of DNA samples.
10:35
Studies of Bacterial Chemotaxis Using Microfluidics - Interview
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Cited by 1 •
2007
14:48
PDMS Device Fabrication and Surface Modification
0 Views •
Cited by 5 •
2007
09:41
Stretching Micropatterned Cells on a PDMS Membrane
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Cited by 6 •
2014
This manuscript presents a technique to apply or release forces on adherent cells or tissues using unidirectional stretching.
FAQs
Optical clarity makes it possible to observe fluids, cells, and biomolecules within the device, while gas permeability can support cell-culture environments that require exchange with surrounding gases. Together with PDMS flexibility, these properties make experiments easier to monitor and help researchers construct microenvironments where biological behavior can be studied under controlled microscale conditions.
The microscale format gives researchers control over very small fluid volumes while also providing pathways for handling cells and biomolecules. This control is central to PDMS microfluidics because it connects device geometry with biological experimentation: researchers can organize transport and exposure within enclosed pathways, then use the platform to reproduce aspects of tissue-relevant microenvironments.
Bonding the cured PDMS replica to glass or another surface closes the previously open channel geometry and creates enclosed pathways for fluid handling. When glass is used, the assembled device also retains a transparent viewing surface. This assembly step converts the molded replica into a usable microfluidic structure for manipulating fluids, cells, or biomolecules.
A typical fabrication workflow begins with a patterned mold, followed by casting PDMS against that pattern and curing the polymer to form a replica. Researchers then bond the cured piece to glass or another surface. This sequence supports rapid prototyping because channel layouts can be reproduced from patterned molds before the finished device is used for experiments.
Researchers select these devices when an experiment benefits from controlled microscale handling of fluids, cells, or biomolecules. Supported uses include cell culture, drug screening, diagnostic assays, and droplet generation. The same platform can therefore serve both biological investigation and assay development, with the application determined by what the channels are designed to handle.
In bioengineering, PDMS microfluidics provides a platform for constructing organ-on-chip models and other tissue-relevant environments. Its transparent material and ability to manipulate small volumes make it suitable for integrating biological components into microscale systems. These models help researchers reproduce tissue-relevant microenvironments in a controlled device, linking materials engineering with studies of cellular behavior and biological response.