Model Predictive Control

Model Predictive Control (MPC) is an advanced control method that uses a mathematical model of a dynamic system to predict future behavior and choose actions while respecting operational constraints. At each sampling interval, MPC solves an optimization problem over a moving time horizon, applies only the first control input, then updates its predictions using new measurements; this repeated feedback process enables proactive correction of disturbances and changing conditions. In engineering, MPC regulates multivariable processes in chemical plants, energy systems, vehicles, and robotics, where interactions, delays, and limits complicate conventional control. Its ability to balance competing objectives supports safer operation, improved efficiency, and more consistent performance.

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Research

JoVE Journal - Bioengineering

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers

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Cited by 6 •

2017

We present a novel method that uses photo-responsive block copolymers for more efficient spatiotemporal control of gene silencing with no detectable off-target effects. Additionally, changes in gene expression can be predicted using straightforward siRNA release assays and simple kinetic modeling.

Predicting the Effectiveness of Population Replacement Strategy Using Mathematical Modeling

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Cited by 3 •

2007

Charles Taylor and John Marshall explain the utility of mathematical modeling for evaluating the effectiveness of population replacement strategy. Insight is given into how computational models can provide information on the population dynamics of mosquitoes and the spread of transposable elements through A. gambiae subspecies. The ethical considerations of releasing genetically modified mosquitoes into the wild are discussed.

Education

JoVE Core - Chemistry

Predicting Molecular Geometry

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2020

VSEPR Theory for Determination of Electron Pair Geometries The following procedure uses VSEPR theory to determine the electron pair geometries and the molecular structures: Write the Lewis structure of the molecule or polyatomic ion. Count the number of electron groups (lone pairs and bonds) around the central atom. A single, double, or triple bond counts as one region of electron density. Identify the electron-pair geometry based on the number of electron groups: linear, trigonal planar,...

Research

JoVE Journal - Biology
Free Sample

A Protocol for Computer-Based Protein Structure and Function Prediction

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Cited by 79 •

2011

Guidelines for computer based structural and functional characterization of protein using the I-TASSER pipeline is described. Starting from query protein sequence, 3D models are generated using multiple threading alignments and iterative structural assembly simulations. Functional inferences are thereafter drawn based on matches to proteins with known structure and functions.

Research

JoVE Journal - Medicine

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

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2025

This study proposed an age-adjusted regression modeling using midface and cranial base morphology as a potential tool for preoperative evaluation and individualized surgical planning for children with syndromic craniosynostosis (SC).

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