Hindlimb Grasp Reflex

The hindlimb grasp reflex is an involuntary behavioral response in which an animal flexes its toes or hind paw after stimulation of the limb, providing a measurable indicator of sensorimotor function. Sensory receptors in the skin and deeper tissues detect contact, and neural circuits in the spinal cord coordinate muscle activation that closes the digits around a surface or stimulus. Researchers use this reflex in behavioral neuroscience to assess motor development, tactile processing, spinal cord circuitry, and changes caused by injury, disease, or experimental treatment. Its strength, timing, and persistence can reveal alterations in nervous system function.

Hindlimb Grasp Reflex - Related Videos

Research

JoVE Journal - Behavior

Neurodevelopmental Reflex Testing in Neonatal Rat Pups

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Cited by 74 •

2017

Behavioral testing is the gold standard for determining outcomes following brain injury, and can identify the presence of developmental disabilities in infants and children. Neurodevelopmental reflexes are an early indicator of these abnormalities. A host of easily accomplished developmental reflex tests in the neonatal rodent were developed and described here.

Partial Heterotopic Hindlimb Transplantation Model in Rats

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Cited by 11 •

2021

This paper presents a partial heterotopic osteomyocutaneous flap transplantation protocol in rats and its potential outcomes in the mid-term follow-up.

Research

JoVE Journal - Biology

Terminal H-reflex Measurements in Mice

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Cited by 3 •

2022

The clinical evaluation of spasticity based on the Hoffmann reflex (H-reflex) and using electrical stimulation of peripheral nerves is an established method. Here, we provide a protocol for a terminal and direct nerve stimulation for H-reflex quantification in the mouse forepaw.

Methods for Acute and Subacute Murine Hindlimb Ischemia

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Cited by 29 •

2016

Surgical induction of hindlimb ischemia in the mouse is useful to examine angiogenesis, however this is compromised in certain inbred mouse strains that display marked ischemia-induced tissue necrosis. Methods are described to induce subacute limb ischemia using ameroid constrictors to circumvent this problem through the induction of gradual arterial occlusion.

Hindlimb Skeletal Muscle Extraction: A Procedure to Excise Hindlimb Skeletal Muscles from Murine Model

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2023

In this video, we describe the procedure to excise hindlimb skeletal muscles from a mouse model. The excised muscles can be stored at lower temperatures until further downstream...

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