Operant Task Mice

Operant task mice are laboratory mice trained to perform actions that produce defined consequences, providing a controlled model for studying how behavior is learned and regulated. In an operant chamber, actions such as a nose poke or lever press are shaped by reinforcement contingencies, with rewards or other outcomes delivered according to schedules that link response patterns to consequences. Researchers use these tasks to measure learning, motivation, decision-making, impulse control, and behavioral flexibility while examining underlying neural circuits and pharmacological effects. Findings can clarify mechanisms of behavior and support research on conditions involving altered cognition, reward processing, or self-control.

Operant Task Mice - Related Videos

Research

JoVE Journal - Behavior
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An Operant Intra-/Extra-dimensional Set-shift Task for Mice

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Cited by 13 •

2016

Attentional set-shifting cognitive abnormalities are a core feature of many psychiatric diseases. Here, we present the development of a novel automatic system for the effective study of attentional set-shifting abilities, executive functions and other cognitive abilities in mice with high translational validity to human studies.

Research

JoVE Journal - Behavior
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Quantifying Social Motivation in Mice Using Operant Conditioning

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Cited by 34 •

2015

This article describes a new protocol for the quantitative measurement of social motivation in mice using operant conditioning for a social reward. The protocol is useful for the measurement of social motivation in mouse models of autism and other disorders of social behavior.

Research

JoVE Journal - Behavior
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Behavioral Tasks for Examining Identity Recognition In Mice

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2025

By pairing negatively or positively valenced experiences with individual social targets, we developed behavior tasks for examining the identity recognition of C57BL/6 mice. These tasks allow for the study of mechanisms of social memory of individual social targets in healthy and disease-related mouse models with impaired social cognition.

Research

JoVE Journal - Biology

Bulk Electroacupuncture Operation for Mice or Young Rats

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2023

Here, we present a protocol for efficient and rapid electroacupuncture (EA) in mice or young rats using a three-dimensional (3D) printed holder. This technique allows simultaneous operation on multiple animals, saving time and increasing experimental efficiency.

Research

JoVE Journal - Neuroscience
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T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

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Cited by 92 •

2012

This article presents the protocol of T-maze tests using a modified automated apparatus for assessing the learning and memory functions in mice.

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