Shock Tolerance Assessment

Shock tolerance assessment is a behavioral method used to measure how an organism responds to a controlled aversive stimulus and why that response matters for motivation, learning, and welfare research. In a typical assessment, researchers vary the intensity or duration of an electrical shock while recording behaviors such as avoidance, escape, latency, persistence, or willingness to continue a task for a reward. These observations help distinguish sensitivity to aversion from changes in decision-making or performance. In behavior studies, the method can support comparisons across individuals, experimental conditions, or interventions while requiring careful control of stimulus parameters and ethical safeguards.

Shock Tolerance Assessment - Related Videos

Research

JoVE Journal - Neuroscience
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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

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Cited by 43 •

2014

We describe a protocol to examine the development of opioid-induced hyperalgesia and tolerance in mice. Based on the measurement of thermal and mechanical nociceptive responses of naïve and morphine-treated animals, it allows to quantify the increase in pain sensitivity (hyperalgesia) and decrease in analgesia (tolerance) associated with chronic opiate administration.

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JoVE Journal - Neuroscience
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Drosophila Adult Olfactory Shock Learning

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Cited by 36 •

2014

The method to measure adult Drosophila associative memory is described. The assay is based on the ability of the fly to associate an odor presented with a negative reinforcer (electric shock) and then recall this information at a later time, allowing memory to be measured.

Education

JoVE Science Education - Basic Biology

Bacterial Transformation: The Heat Shock Method

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2023

Transformation is the process that occurs when a cell ingests foreign DNA from its surroundings. Transformation can occur in nature in certain types of bacteria. In molecular biology, transformation is artificially reproduced in the lab via the creation of pores in bacterial cell membranes. Bacterial cells that are able to take up DNA from the environment are called competent cells. In the laboratory, bacterial cells can be made competent and DNA subsequently introduced by a procedure called...

Research

JoVE Journal - Medicine
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Developing a Clinically Relevant Hemorrhagic Shock Model in Rats

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Cited by 1 •

2024

Hemorrhagic shock kills 1.9 million people worldwide every year. Small animals are frequently used as hemorrhagic shock models but are associated with issues of standardization, reproducibility, and clinical significance, thus limiting their relevance. This article describes developing a new clinically relevant hemorrhagic shock model in rats.

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JoVE Journal - Neuroscience
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Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability

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Cited by 49 •

2017

This manuscript provides an updated remote supervision protocol that enables participation in transcranial direct current stimulation (tDCS) clinical trials while receiving treatment sessions from home. The protocol has been successfully piloted in both patients with multiple sclerosis and Parkinson's disease.

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