Dynamic Force Spectrum
Dynamic Force Spectrum - Related Videos
02:37
The Electromagnetic Spectrum
0 Views •
2020
The electromagnetic spectrum consists of all the types of electromagnetic radiation arranged according to their frequency and wavelength. Each of the various colors of visible light has specific frequencies and wavelengths associated with them, and you can see that visible light makes up only a small portion of the electromagnetic spectrum. Because the technologies developed to work in various parts of the electromagnetic spectrum are different, for reasons of convenience and historical...
04:56
High-Speed Time-Lapse Atomic Force Microscopy to Capture Nucleosome Dynamics
0 Views •
2025
In this video, we demonstrate high-speed time-lapse atomic force microscopy, AFM, imaging techniques to study the dynamics of nucleosome complexes. As the AFM tip scans across the surface of the nucleosome, it detects alterations in the nucleosome height and records the DNA unwrapping over time.
01:19
IR Spectrum
0 Views •
2024
When infrared (IR) radiation passes through a molecule, the bonds stretch or bend by absorbing the radiation. This absorption creates the molecule's absorption spectrum, which is the plot of its percentage transmittance versus wavenumber. Transmittance is defined as the ratio of the radiant power passing through a sample to that from the radiation's source. Multiplying the transmittance by 100 gives the percent transmittance (%T), which varies between 100% (no absorption) and 0% (complete...
07:53
Analyses of Actin Dynamics, Clutch Coupling and Traction Force for Growth Cone Advance
0 Views •
Cited by 10 •
2021
To advance, growth cones must exert traction forces against the external environment. The generation of traction forces is dependent on actin dynamics and clutch coupling. The present study describes methods for analyzing actin dynamics, clutch coupling and traction forces for growth cone advance.
10:02
Executive Function in Autism Spectrum Disorder
0 Views •
2023
Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel—University of Southern California Attention, working-memory, planning, impulse control, inhibition, and mental flexibility are important components of human cognition that are often referred to as executive functions. Autism spectrum disorder is a developmental disorder that is characterized by impairments in social interaction, communication, and repetitive behaviors. It is a disorder that lasts a lifetime, and is thought to affect...
FAQs
Changing loading rate or frequency can reveal mechanical behaviors that may not appear under a single loading condition. A biological sample may respond differently when force changes rapidly than when it changes slowly, allowing investigators to examine time-dependent deformation, viscoelastic behavior, adhesion, or molecular bond dissociation. Comparing these responses helps distinguish rate-sensitive features from more persistent mechanical characteristics.
The recorded force response can contain signatures of several processes, including deformation of a biological material, viscoelastic relaxation, adhesive interactions, and bond dissociation. These features reflect different aspects of how cells, tissues, materials, or molecular interactions respond to force. Interpreting them across conditions helps connect measured mechanics with structural properties and the kinetics of force-dependent interactions.
A single force measurement provides limited information about how a system behaves over time. A force spectrum adds comparative information by showing how the response changes with loading rate or frequency. This comparison can link mechanical measurements to underlying structure and kinetics, helping investigators determine whether an observed response reflects material behavior, adhesion, deformation, or changes in molecular interactions.
The workflow begins by selecting a biological material, cell, tissue, or molecular interaction and applying a controlled load that changes over time. The resulting force response is recorded under defined loading conditions. Investigators then repeat the measurement across different rates or frequencies and compare the resulting responses to identify time-dependent mechanical or interaction-related features.
This approach can be applied to biological materials, individual cells, tissues, and molecular interactions. The selected sample depends on the bioengineering question, such as examining tissue mechanics, cell-material adhesion, or biomolecular binding. Because the method compares force responses under controlled dynamic conditions, it can relate measurements from these different systems to their structural and kinetic behavior.
Bioengineers can use this framework to investigate cell-material interactions, biomolecular binding, and tissue mechanics. It also supports the design and evaluation of engineered biomaterials and medical devices by revealing how biological systems respond to changing mechanical conditions. The resulting comparisons provide information for relating measured force behavior to material performance and biological interaction dynamics.