Hydrogel Formulation
Hydrogel Formulation - Related Videos
07:25
Collagen Hydrogels
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2023
Collagen is another widely used biomaterial that has found popularity in commercial applications, such as photography. Collagen has more recently been used in tissue engineering applications, by creating hydrogels that provide structure to engineered tissue. This video introduces collagen as a biomaterial, demonstrates how it is harvested from porcine skin, and shows how the material is used to create a hydrogel for tissue engineering applications. Finally, several applications of the material...
08:34
Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
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Cited by 59 •
2016
We describe a set of protocols that together provide a tissue-mimicking hydrogel bioink with which functional and viable 3-D tissue constructs can be bioprinted for use in in vitro screening applications.
08:33
Hydrogel Synthesis
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2023
Source: Amber N. Barron, Ashlea Patterson, and Taylor D. Sparks, Department of Materials Science and Engineering, The University of Utah, Salt Lake City, UT Hydrogels are a versatile class of cross-linked polymers produced through relatively simple procedures and with generally inexpensive materials. They can be formed from solution and involve a polymer backbone formed from monomer reagents, an initiator which makes the polymer reactive and a crosslinking species which binds the polymer chains...
10:18
Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications
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Cited by 23 •
2022
This work describes straightforward, adaptable, and low-cost methods to fabricate microgels with extrusion fragmentation, process the microgels into injectable granular hydrogels, and apply the granular hydrogels as extrusion printing inks for biomedical applications.
10:28
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
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Cited by 21 •
2015
Supramolecular hydrogelators based on ureido-pyrimidinones allow full control over the macroscopic gel properties and the sol–gel switching behavior using pH. Here, we present a protocol for formulating and injecting such a supramolecular hydrogelator via a catheter delivery system for local delivery directly in relevant areas in the pig heart.
FAQs
Crosslinking determines how polymer chains are connected and strongly influences the resulting material. Covalent bonding, ionic interactions, and physical assembly provide different ways to establish the three-dimensional network. Selecting among these mechanisms allows researchers to adjust swelling, mechanical strength, porosity, degradation, and molecular transport for a particular biomedical engineering purpose.
Polymer concentration, crosslinker chemistry, and processing conditions are central variables in hydrogel formulation. Changing these factors alters the balance among water uptake, structural strength, pore characteristics, degradation, and transport through the material. Researchers therefore tune the formulation according to whether the intended use prioritizes cell support, therapeutic delivery, tissue integration, or another biomedical outcome.
These properties determine how the material interacts with its aqueous and biological environment. Swelling describes water uptake, porosity affects the available structure within the network, and molecular transport governs movement through the formulation. Controlling them helps researchers create hydrogels that maintain suitable conditions for encapsulated cells, proteins, or therapeutic compounds while supporting the intended application.
A formulation workflow begins by selecting hydrophilic polymers and a suitable crosslinking approach, followed by adjustment of polymer concentration, crosslinker chemistry, and processing conditions. Researchers can then incorporate cells, proteins, or therapeutic compounds as required. The resulting design is judged against target properties such as swelling, mechanical strength, porosity, degradation, and molecular transport.
Researchers choose these formulations when a water-rich material with tunable properties is useful for a biological task. Applications include tissue engineering, drug delivery, wound care, and three-dimensional cell culture. In each setting, the formulation can be adjusted to support different requirements, including cell encapsulation, therapeutic compound release, aqueous support, or tissue integration.
In bioengineering, formulation provides a way to match material behavior with biological objectives. Hydrogels can encapsulate cells or proteins, create aqueous environments for three-dimensional culture, and carry therapeutic compounds. Their adjustable mechanical properties, degradation, transport, and biocompatibility help researchers investigate tissue-related systems and design materials for delivery, repair, or integration.