Platinum Release
Platinum Release - Related Videos
09:40
Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer
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Cited by 2 •
2024
Tropomodulin 3 (TMOD3) has been increasingly studied in tumors in recent years. This study is the first to report that TMOD3 is highly expressed in ovarian cancer and is closely associated with platinum resistance and immune infiltration. These results could help improve the therapeutic outcomes for ovarian cancer.
07:20
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Cited by 1 •
2014
This protocol describes the use of amide coupling reactions of isonicotinic acid and diaminoalkanes to form bridging ligands suitable for use in the synthesis of multinuclear platinum complexes, which combine aspects of the anticancer drugs BBR3464 and picoplatin.
12:08
Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes
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Cited by 4 •
2022
This protocol shows a convenient method for comparing the catalytic properties of supported platinum catalysts, synthesized by deposition of nanosized colloids or by impregnation. The hydrogenation of cyclohexene serves as a model reaction to determine the catalytic activity of the catalysts.
08:32
Electrochemical Roughening of Thin-Film Platinum Macro and Microelectrodes
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2019
This protocol demonstrates a method for electrochemical roughening of thin-film platinum electrodes without preferential dissolution at grain boundaries. The electrochemical techniques of cyclic voltammetry and impedance spectroscopy are demonstrated to characterize these electrode surfaces.
09:02
Synthesis of Platinum-nickel Nanowires and Optimization for Oxygen Reduction Performance
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2018
The protocol describes the synthesis and electrochemical testing of platinum-nickel nanowires. Nanowires were synthesized by the galvanic displacement of a nickel nanowire template. Post-synthesis processing, including hydrogen annealing, acid leaching, and oxygen annealing were used to optimize nanowire performance and durability in the oxygen reduction reaction.
FAQs
Material composition determines which platinum-containing species are available for liberation, while surface chemistry governs how readily the surrounding environment interacts with the solid. These factors can change the rate and overall profile of release, making them important design variables when developing platinum-containing implants, electrodes, catalysts, or drug-delivery systems.
The surrounding fluid, pH, temperature, and exposure time can substantially affect the amount and rate of platinum becoming available. Because these variables interact with the material surface and composition, changing them may produce different release profiles. Controlling them during evaluation helps researchers distinguish material behavior from effects caused by the test environment.
Dissolution, corrosion, and degradation describe different routes through which a solid material can lose platinum or platinum-containing compounds to its surroundings. The dominant process depends on the material and exposure conditions. Identifying which process controls release helps researchers interpret changes in material stability and anticipate how performance may evolve during use.
A basic evaluation exposes the platinum-containing material to a defined surrounding fluid for a specified period while controlling relevant conditions such as pH and temperature. Researchers then assess the platinum released across the exposure interval and organize the results as a release profile. Comparing profiles under different conditions reveals how the material behaves.
Release profiles show how platinum availability changes with exposure time and environmental conditions. Researchers can use these patterns to evaluate material stability and biocompatibility, rather than relying only on the material’s initial composition. The results also help identify designs that may provide more predictable biological or therapeutic responses in biomedical applications.
In bioengineering, release analysis supports decisions about platinum-containing implants, electrodes, catalysts, and drug-delivery systems. Researchers can relate the observed profile to material performance, stability, and potential biological effects. This context is especially valuable when designing systems that must behave predictably in surrounding fluids and maintain an appropriate balance between function and biocompatibility.