Simulated Body Fluid
Simulated Body Fluid - Related Videos
12:39
Computational Fluid Dynamics Simulations of Blood Flow in a Cerebral Aneurysm
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2023
Source: Joseph C. Muskat, Vitaliy L. Rayz, and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana The objective of this video is to describe recent advancements of computational fluid dynamic (CFD) simulations based on patient- or animal-specific vasculature. Here, subject-based vessel segmentations were created, and, using a combination of open-source and commercial tools, a high-resolution numerical solution was determined within a flow model.
01:29
Composition of Body Fluids
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2024
Water functions as a solvent accommodating various solutes, which can be categorized under electrolytes and non-electrolytes. Non-electrolytes are usually held together by covalent bonds, restricting them from dissociating in solution, thereby leading to a lack of electrically charged components upon dissolving in water. They are predominantly organic molecules, such as glucose, creatinine, and urea. Electrolytes, on the other hand, are compounds that can break down into ions in water.
01:19
Body Water Content and Fluid Compartments
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2024
Life's biochemical processes occur within aqueous solutions. Solutes are substances that are dissolved within these solutions. The human body contains a variety of solutes, which can differ across various body parts. These can encompass proteins—such as those responsible for clotting and carbohydrate transport—as well as electrolytes. In medicine, an electrolyte is often described as a mineral ion derived from a salt possessing an electric charge. Examples include sodium ions (Na+) and chloride...
10:20
In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids
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Cited by 2 •
2022
A pendant drop surface film balance implemented with a multi-subphase exchange, nicknamed the OCTOPUS, allows for mimicking digestive conditions by the sequential subphase exchange of the original bulk solution with simulated gastrointestinal fluids. The simulated in vitro digestion is monitored by recording in situ the interfacial tension of the digested interfacial layer.
05:04
Using Simulation Models to Train Clinicians in the Use of Point-of-Care Ultrasound
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2024
The present protocol describes an ideal solution to train novices in the use of point-of-care ultrasound devices for the practical clinical skill of visually assessing distinct individual anatomical vascular conditions prior to and during an intended venous vascular cannulation using point-of-care ultrasound in a patient.
FAQs
At the material surface, ion exchange with the surrounding solution can alter local ion concentrations. When those changes produce supersaturation, apatite can nucleate and grow as a bone-like layer. This sequence links surface chemistry to the visible test outcome: a deposited apatite layer indicates that the material supported conditions favorable to mineral formation in vitro.
Temperature and pH are controlled because they influence the solution environment in which ion exchange and mineral formation occur. Holding these conditions steady makes comparisons among ceramics, glasses, coatings, and implant surfaces more interpretable. If conditions vary between tests, differences in apatite formation may reflect the testing environment rather than the material’s surface behavior.
Apatite formation provides an in vitro indicator of a material’s potential bioactivity, particularly when the material is intended for bone-related use. It shows that the surface can support formation of a bone-like mineral layer under the test conditions. However, this result serves as an early evaluation before more complex biological studies, rather than replacing those studies.
An SBF evaluation begins by immersing the candidate material in the solution, then maintaining controlled temperature and pH during exposure. Afterward, researchers examine whether a bone-like apatite layer formed at the surface. The same workflow can be applied to ceramics, glasses, coatings, and implant surfaces, enabling direct in vitro comparison across material designs.
Researchers look for nucleation and growth of a bone-like apatite layer on the immersed surface. Its formation provides a measurable outcome for comparing how different biomaterials behave under the same controlled solution conditions. This surface response is especially relevant when screening materials intended for bone repair, because it supplies evidence of potential bioactivity before advanced biological testing.
In bioengineering, SBF testing helps guide the development and comparison of materials for bone repair, tissue engineering, and regenerative medicine. Researchers can evaluate ceramics, glasses, coatings, and implant surfaces in a controlled in vitro setting before moving to more complex biological studies. The approach therefore supports early-stage material selection and surface-design decisions.