Architectural Domes

Architectural domes are curved, shell-like structures that span large spaces by transferring loads through their surface rather than relying on interior columns. Their geometry directs gravity and other applied forces primarily into compression along meridional and hoop paths, while supports must resist the resulting outward thrust; material choice, thickness, curvature, and reinforcement determine stability and performance. Engineers analyze domes using structural mechanics, numerical modeling, and construction methods suited to concrete, steel, masonry, or composite systems. These principles support roofs for stadiums, religious buildings, halls, and infrastructure, while informing safer, lighter designs that use materials efficiently and accommodate wind, seismic, and service loads.

Architectural Domes - Related Videos

Education

JoVE Core - Pharmacokinetics and Pharmacodynamics

Dose Size and Dosing Frequency: Determination Methods

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2025

Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...

Research

JoVE Journal - Medicine

Detection of Architectural Distortion in Prior Mammograms via Analysis of Oriented Patterns

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Cited by 14 •

2013

We demonstrate methods for the detection of architectural distortion in prior mammograms. Oriented structures are analyzed using Gabor filters and phase portraits to detect sites of radiating tissue patterns. Each site is characterized and classified using measures to represent spiculating patterns. The methods should assist in the detection of breast cancer.

Minimal Erythema Dose (MED) Testing

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Cited by 74 •

2013

This article describes how to conduct minimal erythema dose (MED) testing in order to determine the lowest dose of ultraviolet radiation that will cause erythema (burning) when administered to an individual.

Rational Dosage Regimen: Maintenance Dose and Loading Dose

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2023

A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects. In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady state,...

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

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2025

A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...

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