Inflection Point

An inflection point is a point on a curve where its concavity changes, marking a transition in how the curve bends and revealing important features of a function’s local shape. To identify one, examine the behavior of the first derivative or the sign of the second derivative on either side of a candidate; although the second derivative may be zero or undefined at the point, that condition alone does not establish an inflection point. Inflection points are useful in calculus for curve sketching, analyzing changing rates, and interpreting transitions in mathematical models of motion, growth, and other real-world relationships.

Inflection Point - Related Videos

Research

JoVE Journal - Immunology and Infection
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Use of Galleria mellonella as a Model Organism to Study Legionella pneumophila Infection

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Cited by 108 •

2013

The larva of the wax moth Galleria mellonella was recently established as an in vivo model to study Legionella pneumophila infection. Here, we demonstrate fundamental techniques to characterize the pathogenesis of Legionella in the larvae, including inoculation, measurement of bacterial virulence and replication as well as extraction and analysis of infected hemocytes.

Research

JoVE Journal - Immunology and Infection

Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis

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Cited by 3 •

2016

This manuscript describes the use of a bioluminescent strain of African trypanosomes to enable the tracking of late stage infection and demonstrates how in vivo live imaging can be used to visualize infections within the central nervous system in real-time.

Research

JoVE Journal - Immunology and Infection
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Infection of Zebrafish Embryos with Intracellular Bacterial Pathogens

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Cited by 218 •

2012

Transparent zebrafish embryos have proved useful model hosts to visualize and functionally study interactions between innate immune cells and intracellular bacterial pathogens, such as Salmonella typhimurium and Mycobacterium marinum. Micro-injection of bacteria and multi-color fluorescence imaging are essential techniques involved in the application of zebrafish embryo infection models.

4D Multimodality Imaging of Citrobacter rodentium Infections in Mice

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Cited by 19 •

2013

Multi-modality imaging is a valuable approach for studying bacterial colonization in small animal models. This protocol outlines infection of mice with bioluminescent Citrobacter rodentium and the longitudinal monitoring of bacterial colonization using composite 3D diffuse light imaging tomography with μCT imaging to create a 4D movie of C. rodentium infection.

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

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Cited by 78 •

2014

We describe the agar-beads method to establish persistent long-term chronic Pseudomonas aeruginosa airway infection in the mouse model.

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