Left Ventricular Function

Left ventricular function refers to the ability of the heart’s left ventricle to fill with oxygenated blood from the left atrium and pump it through the aorta to the systemic circulation, making it central to tissue perfusion. During diastole, the ventricle relaxes and fills; during systole, coordinated myocardial contraction raises intraventricular pressure, closes the mitral valve, and opens the aortic valve. Clinicians assess left ventricular function using echocardiography, ejection fraction, ventricular volumes, wall motion, and pressure measurements. These measures help identify systolic or diastolic dysfunction, guide diagnosis and treatment of heart failure, ischemic disease, and cardiomyopathies, and monitor response to therapy.

Left Ventricular Function - Related Videos

Research

JoVE Journal - Medicine

Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice

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Cited by 2 •

2022

The present protocol describes the echocardiographic assessment of left ventricular morphology, function, and coronary blood flow in 7-day old neonate mice.

Research

JoVE Journal - Medicine
Free Sample

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

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Cited by 34 •

2013

This article describes procedures for implanting a novel hydrogel in failing hearts and quantifying its effect on left ventricular wall stress and function. These procedures have been successfully applied in dogs and humans.

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

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Cited by 5 •

2020

In this article, we provide a step-by-step acquisition and analysis protocol for the volumetric assessment and speckle-tracking analysis of the left ventricle by 3D echocardiography, particularly focusing on practical aspects that maximize the feasibility of this technique.

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

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Cited by 8 •

2021

This study describes a comprehensive cardiovascular magnetic resonance imaging (CMR) protocol to quantify the left ventricular functional parameters of the mouse heart. The protocol describes the acquisition, post-processing, and analysis of the CMR images as well as assessment of different cardiac functional parameters.

Measuring Left Ventricular Pressure in Late Embryonic and Neonatal Mice

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Cited by 17 •

2012

Measuring left ventricular pressure (LV) in embryonic and neonatal mice is described. Pressure is measured by inserting a needle connected to a fluid-filled transducer into the LV under ultrasound guidance. Care must be taken to maintain normal cardiac function during the experimental protocol.

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