Ocular Lens Compression

Ocular lens compression is the deformation of the eye’s crystalline lens when an external force or internal load is applied, providing a way to study lens biomechanics and its role in vision. During compression, the lens changes shape as its elastic and viscoelastic properties resist deformation, while tissue composition, geometry, and boundary conditions influence the measured response. In bioengineering, compression testing and related mechanical models help quantify lens stiffness, characterize age- or disease-related changes, and investigate accommodation, the process that focuses light at different distances. These insights support improved ocular simulations, diagnostic approaches, and designs for artificial or tissue-engineered lenses.

Ocular Lens Compression - Related Videos

Research

JoVE Journal - Bioengineering

Automated Compression Testing of the Ocular Lens

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Cited by 2 •

2024

We present an automated method for characterizing the effective elastic modulus of an ocular lens using a compression test.

Sequential Application of Glass Coverslips to Assess the Compressive Stiffness of the Mouse Lens: Strain and Morphometric Analyses

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Cited by 28 •

2016

Age-related increases in eye lens stiffness are linked to presbyopia. This protocol describes a simple, cost-effective method for measuring mouse lens stiffness. Mouse lenses, like human lenses, become stiffer with age. This method is precise and can be adapted for lenses from larger animals.

RNA Isolation from Mouse Ocular Lens Epithelium and Fiber Cell Bulk Masses

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2025

This protocol details the separation of the mouse ocular lens epithelium and fiber cell bulk mass, followed by RNA isolation and qPCR analysis. This method allows for separating lens cell compartments for a more detailed analysis of the transcriptome and biological processes in epithelial cells vs. differentiated fiber cells.

Eye Lens Dissection: A Technique to Observe Zebrafish Lens Morphology

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2023

This video describes the protocol which is developed to dissect adult and larval zebrafish lenses to analyze cortical lens morphology and structural integrity of the lens sutures.

Intravitreous Injection for Establishing Ocular Diseases Model

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Cited by 38 •

2007

Intravitreous injection is a widely used technique in visual sciences research for ocular diseases or as direct application of local treatment. This video demonstrated a protocol for intravitreous injection using a 1ml syringe with glass pipette. Useful tips about avoiding massive bleeding and lens damage are given.

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