Trabecular Thickness
Trabecular Thickness - Related Videos
09:03
Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
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Cited by 7 •
2015
Trabecular meshwork (TM) migration into Schlemm’s canal space can be induced by acute pressure elevation by ophthalmodynamometer, and observed by spectral domain optical coherence tomography. The goal of this method is to quantify the morphometric response of the living outflow tract to acute pressure elevation in living tissues in situ.
08:52
Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
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Cited by 1 •
2022
This methodology article presents a software-assisted quantitative measurement protocol to quantify histologic subchondral bone thickness in murine osteoarthritic knee joints and normal knee joints as controls. This protocol is highly sensitive to subtle thickening and is suitable for detecting early osteoarthritic subchondral bone changes.
07:59
Murine Full-thickness Skin Transplantation
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Cited by 45 •
2017
Murine full-thickness skin transplantation is a well-established model to study rejection in an alloimmune setting. Here, we provide a tutorial of each step involved in performing a BALB/c-->C57BL/6 full-thickness skin transplant.
05:51
Measuring Diaphragm Thickness and Function Using Point-of-Care Ultrasound
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Cited by 9 •
2023
Diaphragm thickness and function can be assessed in healthy individuals and critically ill patients using point-of-care ultrasound. This technique offers an accurate, reproducible, feasible, and well-tolerated method for evaluating diaphragm structure and function.
08:17
Organotypic Culture of Full-thickness Adult Porcine Retina
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Cited by 19 •
2011
Here we describe a cost-effective technique for organotypic culture of adult porcine retina for seven days. Briefly, a sterile filter paper was used to lift the neural retina off from the RPE and place photoreceptor side up on an insert raised by a custom-made stand.
FAQs
Trabecular thickness should be interpreted together with trabecular number, spacing, and connectivity. These measures describe different aspects of the same microarchitectural network, so a thickness value alone does not capture how much structure is present, how widely elements are separated, or how continuously they are linked. Their combined pattern supports more meaningful comparisons across disease, loading, aging, or treatment.
Segmentation is the image-processing step that identifies mineralized tissue within a micro-computed tomography or histological image. Local-distance calculations are then performed on that identified tissue rather than on the entire image. Consequently, the segmentation result establishes which parts of the image contribute to the thickness estimate and provides the basis for quantitatively describing the trabecular network.
Local-distance calculations allow thickness to be estimated across the trabecular network rather than represented by a single observation. Averaging those local measurements produces a summary of the widths of individual struts and plates while retaining a connection to the spatially distributed structure being analyzed. This makes the resulting value useful for comparing microarchitecture under different biological or engineering conditions.
An image-based workflow starts by acquiring a three-dimensional micro-computed tomography scan or a histological image. Mineralized tissue is then segmented, and local distances across the trabecular network are calculated. The resulting measurements are summarized as an average thickness and interpreted with number, spacing, and connectivity. This sequence links image data to a quantitative microarchitectural outcome.
In bioengineering, thickness measurements help evaluate whether bone scaffolds, implant interfaces, and engineered tissue models reproduce relevant features of native bone microarchitecture. Researchers can use the parameter alongside other architectural measures to characterize structural change or support construct evaluation. Its value is therefore comparative: it helps assess how closely an engineered or modified system reflects the intended bone environment.
Changes in trabecular thickness can be examined in relation to disease, mechanical loading, aging, or treatment. Tracking the measure in these contexts helps characterize how the cancellous network changes, especially when thickness is considered with number, spacing, and connectivity. In bioengineering studies, the same framework can guide evaluation of scaffold and tissue-model responses to the condition being studied.