<p class="jove_content">The use of cytokine release assay reference reagents allows for more reproducible and standardized <em>in vitro</em> safety profiles of immunotherapeutic monoclonal antibodies. Here we describe how cytokine release assays can be used alongside a reference reagent panel to predict the safety of some therapeutic monoclonal antibodies.</p>

using-reference-reagents-to-confirm-robustness-cytokine-release

Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety

New immunostimulatory antibody drugs designed to either directly stimulate specific immune cells or indirectly enhance the immune response by blocking or ...

Institution - The Medicines and Healthcare Products Regulatory Agency (MHRA)

Articles Published in JoVE