<p class="jove_content">Inflammatory stress in an IL-1&#946;-induced C28/I2 chondrocyte model increased miR-590-5p and reduced SPRY2 expression. Modulating this axis altered the expression of Beclin-1, LC3-II, and Bcl-2, suggesting a putative miR-590-5p/SPRY2 regulatory pathway that may influence autophagy-associated responses and chondrocyte survival in osteoarthritis.</p>

effects-regulating-spry2-mir-590-5p-expression-on-autophagy-human

Effects of Regulating SPRY2 and miR-590-5p Expression on Autophagy in Human Osteoarthritis Model Chondrocytes

Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by progressive cartilage destruction and loss of chondrocyte homeostasis. ...

<p class="jove_content">This article demonstrates the standardized operation process of Zhuang medicine line moxibustion in experimental animals. To achieve repeatability and accuracy of Zhuang medicine line moxibustion, we developed a simulator to maintain strength, heat, and frequency. We constructed a dysmenorrhea model for experimental verification in rats with cold coagulation syndrome.</p>

medicated-thread-moxibustion-therapy-zhuang-medicine-its-application

Medicated Thread Moxibustion Therapy of Zhuang Medicine and its Application in a Rat Model of Cold-Congealing Syndrome of Primary Dysmenorrhea

Zhuang medicine thread moxibustion therapy is one of the national intangible cultural heritages. It is a Zhuang medicine characteristic therapy that ...

Institution - The First Affiliated Hospital of Guangxi University of Chinese Medicine

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