<p class="jove_content">This protocol provides step-by-step instructions for generating and troubleshooting human acute lymphoblastic leukemia (ALL) xenografts from cell lines and fresh patient material in transiently immunosuppressed zebrafish embryos, along with guidelines for drug response assessment using flow cytometry. The experimental pipeline can also be adapted for solid tumors. </p>

rapid-vivo-drug-response-prediction-using-leukemia-cell-grafts

Rapid <em>in vivo</em> Drug Response Prediction Using Leukemia Cell Grafts in Zebrafish Embryos

Zebrafish xenotransplantation is a pivotal technique for investigating human cancer pathogenesis and predicting individual drug responses. This document ...

Institution - Charité-Universitätsmedizin Berlin, Klinik für Pädiatrie m.S. Onkologie/Hämatologie

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