By conducting both organismal and cell culture-based studies, it was demonstrated that inhibiting Raf kinase inhibitor protein (RKIP) can mitigate neuronal ferroptosis following spontaneous intracerebral hemorrhage, thereby reducing brain injury. The observed cytoprotection arises through NRF2/HO-1 signaling axis modulation.

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Neuronal Ferroptosis Attenuation by RKIP Inhibition Following Spontaneous Intracerebral Hemorrhage via NRF2/HO-1 Pathway Activation

Raf kinase inhibitor protein (RKIP), a primary member of the phosphatidylethanolamine-binding protein family, is recognized for its involvement in various ...

Machine learning models were developed to predict L5-S1 disc herniation recurrence after PEID surgery, analyzing data from 309 patients. Key predictors included BMI and PDHI, with random forest and extreme gradient boosting models showing the best performance.

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The Prediction of Recurrence of Lumbar Disc Herniation at L5-S1 through Machine Learning Based on Endoscopic Discectomy via the Interlaminar Approach

This study aimed to develop machine learning (ML) models to predict the L5-S1 level recurrent lumbar disc herniation (rLDH) after percutaneous endoscopic ...

Institution - Affiliated Hospital 2 of Nantong University

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