<p class="jove_content">Cisplatin (DDP) resistance limits chemotherapy efficacy in lung cancer. This study aimed to elucidate how &#946;-Elemene(&#946;-Ele) reverses resistance in A549/DDP cells by downregulating LINC00511. <em>In vitro</em> and RNA-seq analyses showed that this regulation inhibits aerobic glycolysis and Wnt/&#946;-catenin signaling, offering a potential strategy to overcome chemoresistance.</p>

investigating-mechanism-elemene-mediated-linc00511-modulation-to

Investigating the Mechanism of &#946;-Elemene-Mediated LINC00511 Modulation to Suppress Cisplatin Resistance in Lung Cancer

Cisplatin resistance significantly limits the efficacy of chemotherapy in non-small cell lung cancer, necessitating the development of new strategies to ...

Institution - The Research Center of The Affiliated Hospital to Changchun University of Chinese Medicine

Articles Published in JoVE