<p class="jove_content">Intranasal administration enables direct delivery of bioactive molecules to the brain, providing a non-invasive alternative to the intracerebroventricular method. This study demonstrates that intranasal administration of cyclo<sub>(1-8)</sub>OP, an ODN analog, exerts strong neuroprotective effects against MPTP-induced oxidative damage and apoptosis in the striatum in a mouse model of Parkinson's disease, highlighting therapeutic potential.</p>

neuroprotective-effects-intranasally-administered

Neuroprotective Effects of Intranasally Administered Octadecaneuropeptide Analog in a Mouse Model of MPTP-Induced Parkinson's Disease

Parkinson&#39;s disease (PD) is a neurodegenerative disorder for which existing therapies are primarily palliative and lack curative efficacy. ...

Inserm U1239 NorDiC

Institution - Univ Rouen Normandie

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