<p class="jove_content">Here, we present a protocol to investigate how Mettl3 regulates Nrf2 via m6A modification, thereby suppressing microglial pyroptosis and safeguarding serotonin neurons in Parkinson&#39;s disease models, with applications in epitranscriptomic neuroinflammation research.</p>
<p></p>

mettl3nrf2-axis-suppresses-parkinson-s-disease-progression-via

Mettl3/Nrf2 Axis Suppresses Parkinson&#39;s Disease Progression via Inhibiting NLRP3-Induced Pyroptosis in Serotonin Neurons

The precise mechanisms underlying Parkinson&#39;s disease (PD) pathogenesis remain incompletely understood, particularly regarding the role of microglial ...

Institution - Yantai Yantaishan Hospital

Articles Published in JoVE