<p class="jove_content">Using integrated machine learning across multiple cohorts, we built a robust IMRG prognostic signature for glioma. IRAIN is markedly downregulated, inversely linked to grade and survival, and suppresses IGF1R-JAK2-STAT3-BIRC5 signaling, restraining proliferation, migration, and angiogenesis. Findings nominate IRAIN and IMRGs as biomarkers and therapeutic targets.</p>

long-noncoding-rna-irain-drives-immunometabolic-reprogramming-glioma

Long Noncoding RNA IRAIN Drives Immunometabolic Reprogramming in Glioma via the IGF1R-JAK-STAT-BIRC5 Axis

Glioma is an aggressive malignancy with limited therapeutic options and a poor prognosis. Its progression is closely linked to metabolic reprogramming and ...

Institution - Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical University

Articles Published in JoVE