<p class="jove_content">This protocol describes a reproducible two-sample Mendelian randomization workflow for evaluating the potential causal association between ischemic stroke and vascular dementia using publicly available genome-wide association study summary statistics.</p>

causal-relationship-between-ischemic-stroke-vascular-dementia

Causal Relationship Between Ischemic Stroke and Vascular Dementia: A Mendelian Randomization Study

Ischemic stroke (IS) is a major cause of disability and mortality worldwide, and vascular dementia (VaD) is a common dementia subtype associated with ...

<p class="jove_content">This protocol integrates clinical samples, cultured macrophages, and a cecal ligation and puncture (CLP) mouse model to investigate how the NEAT1/miR-181a-5p/HMGB1 axis regulates macrophage polarization and inflammation in sepsis, providing step-by-step guidance that can be adapted to other lncRNA-mediated immune pathways.</p>

neat1mir-181a-5phmgb1-axis-regulates-macrophage-polarization

NEAT1/miR-181a-5p/HMGB1 Axis Regulates Macrophage Polarization and Inflammation in Sepsis Models

Sepsis is characterized by a dysregulated host immune response and remains a leading cause of mortality worldwide. Long non-coding RNA NEAT1 has been ...

Institution - Affiliated Hospital of Hebei University

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