<p class="jove_content">This protocol describes a single-cell RNA sequencing workflow to analyze immune-cell infiltration and cell-type-specific transcriptional differences between ganglionic and aganglionic colonic segments in Hirschsprung disease.</p>

single-cell-rna-sequencing-for-profiling-ganglionic-aganglionic

Single-cell RNA Sequencing for Profiling Ganglionic and Aganglionic Colonic Segments from Patients with Hirschsprung Disease

Hirschsprung disease (HSCR) is a congenital intestinal motility disorder characterized by the absence of enteric neurons in the distal bowel. Compared ...

<p class="jove_content">In this study, LINC01614 was delivered via exosomes to investigate its mechanism in regulating Treg differentiation and M2 macrophage polarization, thereby remodeling the immune microenvironment in gastric cancer.</p>

exosomal-linc01614-from-gastric-cancer-cells-drives-treg

Exosomal LINC01614 from Gastric Cancer Cells Drives Treg Differentiation

This study aimed to investigate the potential mechanism by which LINC01614, a long non-coding RNA (lncRNA), regulates the immune microenvironment of ...

Institution - The Second Affiliated Hospital of Zunyi Medical University

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