<p class="jove_content">Here, we present an integrated protocol for generating controlled osteochondral lesions in sheep knees to establish an experimental model suitable for bone and cartilage tissue regeneration studies. The protocol outlines a method for inducing a full-thickness osteochondral defect in the femoral condyle, utilizing techniques that minimize animal welfare impacts and variability in results.</p>

establishment-evaluation-sheep-model-full-thickness-osteochondral

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Aging, trauma, genetic predisposition, and lifestyle impact the human body&#180;s cartilage degradation. Once injured, continuous insults resulting from ...

Institution - Carlos Chagas Institute

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