<p class="jove_content">Here, we present a protocol to identify potential anti-tuberculosis drug candidates through phenotypic screening, encompassing the chemical synthesis of a 4-aminoquinoline compound, determination of its minimum inhibitory concentration against Mycobacterium tuberculosis, and assessment of its cytotoxicity in mammalian cell lines.</p>

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Identification of Potential Anti-TB Candidates: A Step-by-Step Guide to Synthesis, MIC Determination, and Cytotoxicity Assessment in Mammalian Cells

Tuberculosis (TB) remains one of the leading causes of death from a single infectious agent worldwide, with rising rates of drug resistance making the ...

Center for Molecular and Functional Biology Research

National Institute of Science and Technology in Tuberculosis

Graduate Program in Cellular and Molecular Biology

School of Health and Life Sciences

Graduate Program in Medicine and Health Sciences

School of Medicine

Center for Molecular and Functional Biology Research, National Institute of Science and Technology in Tuberculosis

Graduate Program in Cellular and Molecular Biology, School of Health and Life Sciences

Graduate Program in Medicine and Health Sciences, School of Medicine

Pontifical Catholic University of Rio Grande do Sul

Institution - Pontifical Catholic University of Rio Grande do Sul

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