<p class="jove_content">Alcohol-associated liver disease progresses through steatosis, inflammation, and fibrosis via microRNA regulatory networks targeting signaling pathways. High-throughput studies reveal dual microRNA roles, yet network-level cooperation and clinical translation remain underexplored. This review synthesizes mechanisms to support early diagnostic biomarkers and targeted therapies.</p>

microrna-regulatory-networks-alcohol-associated-liver-disease

MicroRNA Regulatory Networks in Alcohol-Associated Liver Disease: Mechanisms from Steatosis and Inflammation to Fibrosis

Alcohol-associated liver disease (ALD) is a leading cause of liver-related morbidity and mortality worldwide and progresses through steatosis, ...

<p class="jove_content">Here, we present a protocol to establish an HCl-induced reflux esophagitis cell model using Het-1A cells and to investigate the miR-107/FGFRL1 axis using molecular and cellular assays.</p>

establishment-an-acid-induced-het-1a-cell-model-functional-analysis

Establishment of an Acid-Induced Het-1A Cell Model and Functional Analysis of the miR-107/FGFRL1 Axis

Extensive evidence suggests that microRNAs (miRNAs) play a key role in gastrointestinal pathophysiological processes. However, their specific mechanisms ...

Institution - Jiaozhou Central Hospital of Qingdao

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