<p class="jove_content">Alcohol-associated liver disease progresses through steatosis, inflammation, and fibrosis via microRNA regulatory networks targeting signaling pathways. High-throughput studies reveal dual microRNA roles, yet network-level cooperation and clinical translation remain underexplored. This review synthesizes mechanisms to support early diagnostic biomarkers and targeted therapies.</p>

microrna-regulatory-networks-alcohol-associated-liver-disease

MicroRNA Regulatory Networks in Alcohol-Associated Liver Disease: Mechanisms from Steatosis and Inflammation to Fibrosis

Alcohol-associated liver disease (ALD) is a leading cause of liver-related morbidity and mortality worldwide and progresses through steatosis, ...

<p class="jove_content">This review examines miRNAs in MASH pathogenesis, lipid metabolism, inflammation, and fibrosis, and their promise as biomarkers and therapeutics. Preclinical results are strong, but delivery, targeting, and standardization remain key hurdles. MiRNA-based diagnostics and therapeutics are precision tools for MASH management.</p>

microrna-metabolism-related-fatty-liver-inflammation-mechanisms

MicroRNA In Metabolism-Related Fatty Liver Inflammation: Mechanisms and Clinical Translation Prospects

Metabolic-associated steatohepatitis (MASH) represents a growing global public health challenge. Its complex pathogenesis involves multiple pathological ...

Institution - Qingdao Public Health Clinical Center

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