<p class="jove_content">Inflammatory stress in an IL-1&#946;-induced C28/I2 chondrocyte model increased miR-590-5p and reduced SPRY2 expression. Modulating this axis altered the expression of Beclin-1, LC3-II, and Bcl-2, suggesting a putative miR-590-5p/SPRY2 regulatory pathway that may influence autophagy-associated responses and chondrocyte survival in osteoarthritis.</p>

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Effects of Regulating SPRY2 and miR-590-5p Expression on Autophagy in Human Osteoarthritis Model Chondrocytes

Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by progressive cartilage destruction and loss of chondrocyte homeostasis. ...

Institution - Ruikang Hospital, Guangxi University of Chinese Medicine

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