A Time-Resolved FRET Activity Assay to Distinguish Enzymatic Inhibition from PROTAC-Mediated Degradation of SARS-CoV-2 Mpro0 views•2026•Immunology and Infection•Topical CollectionChristopher Veeck1, Luna Clara Schmacke2, Jasmin Jekkel2, Lennart Laube3, Anke-Dorothee Werner1,4, Wibke Diederich3, Andreas Heine2, Torsten Steinmetzer2, Stephan Becker1,4Christopher Veeck1Luna Clara Schmacke2Jasmin Jekkel2Lennart Laube3Anke-Dorothee Werner1,4Wibke Diederich3Andreas Heine2Torsten Steinmetzer2Stephan Becker1,41Institute of Virology, Philipps-Universität Marburg, 2Institute of Pharmaceutical Chemistry, Philipps-Universität Marburg, 3Center for Tumor Biology and Immunology, Philipps-Universität Marburg, 4Deutsches Zentrum für Infektionsforschung (DZIF), Partner Site Giessen-Marburg-LangenInstitute of Virology, Philipps-Universität MarburgInstitute of Pharmaceutical Chemistry, Philipps-Universität MarburgCenter for Tumor Biology and Immunology, Philipps-Universität MarburgDeutsches Zentrum für Infektionsforschung (DZIF), Partner Site Giessen-Marburg-Langen
