<p class="jove_content">Using bulk, single-cell, and spatial transcriptomic analyses, together with machine-learning-based survival modeling and experimental validation, this study nominates PPARG as a candidate senescence-related prognostic gene in osteosarcoma and associates its reduced expression with adverse survival in TARGET-OS and vascular and microenvironmental features.</p>

integrative-bulk-single-cell-spatial-transcriptomic-analyses-nominate

Integrative Bulk, Single-Cell, and Spatial Transcriptomic Analyses Nominate PPARG as a Candidate Senescence-Related Prognostic Gene in Osteosarcoma

Osteosarcoma remains challenging in metastatic, recurrent, or therapy-resistant disease. This study aimed to identify senescence-related prognostic genes ...

<p class="jove_content">A modified technique combining an orbital septal fascial flap with extended orbital fat release was associated with correction of lower eyelid bags and midface depression, with a low complication rate and favorable aesthetic outcomes in a single-center retrospective cohort.</p>

orbital-septal-fascial-flap-with-extensive-release-long-orbital-fat

Orbital Septal Fascial Flap with Extensive Release of a Long Orbital Fat Flap for Correcting Lower Eyelid Bags Associated with Midface Depression

Conventional lower blepharoplasty remains constrained by limited fat availability and insufficient transposition distance in patients with severe tear ...

Institution - Liuzhou People's Hospital

Articles Published in JoVE