<p class="jove_content">This study investigates NOTCH2-driven colorectal cancer progression using TCGA analysis, clinical samples, HCT116 functional assays, and macrophage co-culture. NOTCH2 overexpression promotes epithelial-mesenchymal transition and is accompanied by coordinated GATA3/IL-4 changes. IL-4 contributes to M2-like macrophage polarization, supporting NOTCH2 as a candidate regulator of tumor-cell plasticity and immune-microenvironment remodeling in CRC.</p>

notch-receptor-2-drives-epithelial-mesenchymal-transition-m2-like

Notch Receptor 2 Drives Epithelial-Mesenchymal Transition and M2-Like Macrophage Polarization in Human Colorectal Cancer Tissues and HCT116 Cells

Despite advances in understanding colorectal cancer (CRC) biology, how tumor-cell signaling coordinates epithelial-mesenchymal transition (EMT) with ...

Institution - Hubei Cancer Clinical Study Center

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