<p class="jove_content">This manuscript describes a workflow to assess platelet-associated Tissue Factor (TF)-dependent thrombin generation in isolated intact human platelets using the calibrated automated thrombogram (CAT). By avoiding exogenous TF and integrating contact pathway inhibition, phospholipid normalization, and TF / Tissue Factor Pathway Inhibitor (TFPI)modulation, this approach enables a specific and physiologically relevant functional assessment of endogenous platelet TF.</p>

protocol-for-assessment-endogenous-platelet-associated-tissue-factor

Protocol for the Assessment of Endogenous Platelet-Associated Tissue Factor-Dependent Thrombin Generation in Human Platelets Using the Calibrated Automated Thrombogram

Institution - Thrombinoscope BV

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