<p class="jove_content">This prospective cohort study evaluates circulating neutrophil extracellular traps (NETs), measured as MPO-DNA complexes, as predictive biomarkers of trastuzumab efficacy in HER2-positive breast cancer. Higher baseline NETs and unfavorable NETs dynamics were associated with disease progression and shorter progression-free survival, supporting NETs as potential adjunctive biomarkers for risk stratification.</p>

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Neutrophil Extracellular Traps as Predictive Biomarkers in Trastuzumab-Treated HER2-Positive Breast Cancer: A Prospective Cohort Study

Neutrophil extracellular traps (NETs) have been implicated in cancer progression and therapy resistance, but their value as predictive biomarkers in ...

Institution - Postgraduate School, Wannan Medical College

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