<p class="jove_content">This meta-analysis of 10 studies (1,478 patients) confirms phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha and B-rapidly accelerated fibrosarcoma-mutations as negative prognostic biomarkers in rat sarcoma viral oncogene homolog wild-type mCRC, associated with worse progression-free and overall survival. No significant impact on objective response was observed. Testing these mutations is recommended to guide treatment.</p>

impact-phosphatidylinositol-3-kinase-b-raf-mutations-rat-sarcoma-wild

Impact of Phosphatidylinositol 3-Kinase and B-Raf Mutations in Rat Sarcoma Wild-Type Metastatic Colorectal Cancer

Activating mutations in phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and B-Raf proto-oncogene (BRAF) are hypothesized ...

Institution - Chinese People's Armed Police Force Hospital of Beijing

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