<p class="jove_content">An <em>in vivo</em> method to test gene function in postnatal brain is described.  Recombinant AAVs expressing Cre and/or a fluorescent protein are injected into neonatal mouse brain.  Mosaic gene inactivation and sparse neuronal labeling are achieved, allowing rapid analysis of gene function in processes critical to neural circuit development.</p>

mosaic-analysis-gene-function-postnatal-mouse-brain-development-using

Mosaic Analysis of Gene Function in Postnatal Mouse Brain Development by Using Virus-based Cre Recombination

Normal brain function relies not only on embryonic development when major neuronal pathways are established, but also on postnatal 
development when ...

Institution - University of Southern California

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