This study applies a graph-theoretical framework to a modeled protein-protein interaction network of the RAS signaling pathway to identify centrally connected zone 1 proteins and characterize their functional and biological relevance.

graph-theoretical-analysis-modeled-protein-protein-interaction

Graph-theoretical Analysis of a Modeled Protein-protein Interaction Network in the RAS Signaling Pathway

The RAS signaling pathway is a fundamental regulator of cellular growth, proliferation, and survival. Dysregulation of this pathway is strongly implicated ...

This protocol presents the slide preparation and automated scoring of the &#947;-H2AX foci assay on peripheral blood lymphocytes. To illustrate the method and sensitivity of the assay, isolated lymphocytes were irradiated in vitro. This automated method of DNA DSB detection is useful for fast and high-throughput biological dosimetry applications.

an-automated-microscopic-scoring-method-for-h2ax-foci-assay-human

An Automated Microscopic Scoring Method for the &#947;-H2AX Foci Assay in Human Peripheral Blood Lymphocytes

Ionizing radiation is a potent inducer of DNA damage and a well-documented carcinogen. Biological dosimetry comprises the detection of biological effects ...

Institution - University of the Western Cape

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