<p class="jove_content">A protocol for performing unilateral 6-OHDA lesions of the medial forebrain bundle in mice is described. This method has a low mortality rate (13.3 %) with 89% of the surviving animals showing &#62;95% loss of striatal dopamine and 90.63&#177;-4.02 % ipsiversive rotational bias towards the side of the lesion.</p>

development-unilaterally-lesioned-6-ohda-mouse-model-parkinson-s

Development of a Unilaterally-lesioned 6-OHDA Mouse Model of Parkinson's Disease

Institution - University of Toronto at Scarborough

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