<p class="jove_content">Subretinal injection has been widely applied in preclinical studies of stem cell replacement therapy for age-related macular degeneration. In this visualized article, we describe a less risky, reproducible and precisely modified subretinal injection technique via the trans-scleral approach to deliver cells into rat eyes.  </p>

development-refined-protocol-for-trans-scleral-subretinal

Development of a Refined Protocol for Trans-scleral Subretinal Transplantation of Human Retinal Pigment Epithelial Cells into Rat Eyes

Degenerative retinal diseases such as age-related macular degeneration (AMD) are the leading cause of irreversible vision loss worldwide. AMD is ...

<p class="jove_content">This surgical technique illustrates the injection of gene therapy vectors and stem cells into the subretinal space of the mouse eye.</p>

subretinal-injection-gene-therapy-vectors-stem-cells-perinatal-mouse

Subretinal Injection of Gene Therapy Vectors and Stem Cells in the Perinatal Mouse Eye

The loss of sight affects approximately 3.4 million people in the United States and is expected to increase in the upcoming years.1 Recently, gene therapy ...

Institution - Neural Stem Cell Institute

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