This study aims to analyze the underlying mechanisms of inflammatory factors associated with atherosclerotic plaques (AP) using RNA-sequencing. The results identified CCL3, CCL4, and CXCL1 key inflammatory hub genes in AP. These chemokines may drive atherosclerosis by promoting M0 macrophage accumulation while suppressing protective immune cells, revealing potential therapeutic targets.

transcriptome-sequencing-identified-hub-pathogenic-chemokines

Transcriptome Sequencing Identified Hub Pathogenic Chemokines In Atherosclerotic Plaques

Atherosclerotic plaque (AP) is a kind of inflammatory fibrous tissue proliferative disease after the injury of endothelial cells and smooth muscle cells ...

The purification of recombinant proteins from plant systems is usually challenged by plant proteins. This work provides a method to effectively extract and purify a secreted recombinant protein from the apoplast of Nicotiana benthamiana.

apoplast-extraction-based-method-to-improve-purity-plant-produced

Apoplast-Extraction Based Method to Improve the Purity of Plant Produced Recombinant Protein

Plants are a newly developing eukaryotic expression system being explored to produce therapeutic proteins. Purification of recombinant proteins from ...

Institution - Shandong First Medical University

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