<p class="jove_content">This protocol describes the establishment of a mouse model of overload stress-induced knee osteoarthritis by combining intra-articular collagenase injections with exercise-induced overexertion, providing a minimally invasive platform for investigating degenerative pathogenesis.</p>

combining-collagenase-injections-with-exercise-induced-mechanical

Combining Collagenase Injections with Exercise-Induced Mechanical Overload: A Mouse Model Simulating Overload Stress Injury Knee Osteoarthritis

Knee osteoarthritis (KOA) is a multifactorial degenerative joint disease driven by the complex interplay of biological tissue degradation and sustained ...

Institution - Shanghai Pudong Hospital

Articles Published in JoVE