<p class="jove_content">This protocol provides a practical framework for designing and operating the IT infrastructure of an in-house Cryogenic electron microscopy (cryo-EM) facility. It covers facility planning, network architecture, storage, GPU computing, remote access, and real-time data processing, enabling efficient management of multi-terabyte datasets while ensuring scalable, sustainable, and high-performance cryo-EM operations.</p>

designing-operating-an-house-cryogenic-electron-microscopy-facility

Designing and Operating an In-House Cryogenic Electron Microscopy Facility with IT Infrastructure and On-the-Fly Data Processing Pipelines

Cryo-EM has become a dominant method for high-resolution structural determination of biological macromolecules. As the number of institutional cryo-EM ...

<p class="jove_content">Lipoxygenase (LOX) isozymes can generate products that may increase or decrease neuroinflammation and neurodegeneration.&#160;A gene-environment interaction study could identify LOX isozyme-specific effects. Using the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of nigrostriatal damage in two LOX isozyme-deficient transgenic lines allows for comparison of the contribution of LOX isozymes on dopaminergic integrity and inflammation.</p>

gene-environment-interaction-models-to-unmask-susceptibility

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Lipoxygenase (LOX) activity has been implicated in neurodegenerative disorders such as Alzheimer&#39;s disease, but its effects in Parkinson&#39;s disease ...

Institution - University of California-Santa Cruz

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