<p class='jove_content'>An ELISA offering a novel quantitative approach is described. It specifically detects disease-associated &#945;-synuclein (&#945;S<sup>D</sup>) in a transgenic mouse model (M83) of synucleinopathy using several antibodies against either the Ser129 phosphorylated &#945;S form or the C-terminal part of the protein.</p>

detection-disease-associated-synuclein-enhanced-elisa-brain

Detection of Disease-associated &#945;-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated &#945;-synuclein

In addition to established methods like Western blot, new methods are needed to quickly and easily quantify disease-associated &#945;-synuclein (&#945;SD) ...

Institution - ANSES - French Agency for Food, Environmental and Occupational Health & Safety

Articles Published in JoVE